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Samir Ghadiali

  • Professor, Pulmonary, Crit Care, & Sleep
  • Professor, Biomedical Engineering
  • 292 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-7742


  • 20140501

    Lumley Research Award.

  • 20080201-20130201

    NSF CAREER Award.

  • 20060601-20110601

    NIH RO1 New Investigator Award.

  • 20100201

    Herman Weed Excellence in Teaching Award.

  • 20050601-20080601

    Parker B. Francis Fellowship in Pulmonary Research.

  • 20050101-20080101

    Frank Hook Assistant Professorship in Bioengineering.

  • 20050101

    US National Committee on Biomechanics New Faculty Award.

  • 20010101-20011201

    Children’s Hospital of Pittsburgh Post-doctoral Research Fellowship.

  • 19940801-19980801

    Louisiana Board of Regents Graduate Study Scholarship.

  • Chair of Respiratory Engineering Track at BMES Annual Meetings in 2009 and 2014.



  • 2013. "microRNAs and Inflammation, 2013." In MicroRNAs in Toxicology and Medicine, edited by Saura Sahu,
  • 2013. "MicroRNAs and Inflammation." In Micro-RNAs in Toxicology and Medicine, edited by Saura Sahu,


  • 2011. "Mechanobiology and finite element analysis of cellular injury during microbubble flows." In Cellular and Biomolecular Mechanics and Mechanobiology, edited by Amit Gefen,


  • 2008. "Computer Modeling in Otitis Media: Perspectives and Limits." In Chronic Otitis Media, Pathology -guided, Pathogenesis-oriented Therapeutic Management, edited by Bernard Ars,

Journal Articles


  • Blackstone, B.N.; Li, R.; Ackerman, W.E.; Ghadiali, S.N. et al., 2015, "Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances Cell-Matrix adhesion in breast cancer cells." American Journal of Physiology - Cell Physiology 308, no. 8, C642-C649 - C642-C649.


  • Volakis, L.I.; Li, R.; Ackerman, W.E.; Mihai, C. et al., 2014, "Loss of myoferlin redirects breast cancer cell motility towards collective migration.." PloS one 9, no. 2, e86110 - e86110.
  • Volakis,Leonithas,I; Li,Ruth; Ackerman,William,E; Mihai,Cosmin; Bechel,Meagan; Summerfield,Taryn,L; Ahn,Christopher,S; Powell,Heather,M; Zielinski,Rachel; Rosol,Thomas,J; Ghadiali,Samir,N; Kniss,Douglas,A, 2014, "Loss of Myoferlin Redirects Breast Cancer Cell Motility towards Collective Migration.." PloS one 9, no. 2, e86110 - e86110.


  • Ma,Xiaoyue; Schickel,Maureen,E; Stevenson,Mark,D; Sarang-Sieminski,Alisha,L; Gooch,Keith,J; Ghadiali,Samir,N; Hart,Richard,T, 2013, "Fibers in the Extracellular Matrix Enable Long-Range Stress Transmission between Cells." BIOPHYSICAL JOURNAL 104, no. 7, 1410-1418 - 1410-1418.


  • Huang,Yan; Crawford,Melissa; Higuita-Castro,Natalia; Nana-Sinkam,Patrick; Ghadiali,Samir,N, 2012, "miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium." FASEB JOURNAL 26, no. 8, 3351-3364 - 3351-3364.


  • Mihai,Cosmin; Zielinski,Rachel; Bao,Shaoying; Knoell,Daren; Ghadiali,Samir, 2011, "PTEN signaling modulates lung epithelial cells migration and wound repair through changes in cellular mechanics." FASEB JOURNAL 25, unknown - unknown.
  • Mengistu, M., Brotzman, H., Ghadiali, S.N., Lowe-Krentz, L., 2011, "Fluid Shear Stress-Induced JNK Activity Leads to Actin Remodeling for Cell Alignment." Journal of Cell Physiology 1, no. 226, 110-121 - 110-121.


  • Huang, Y., Haas, C., Ghadiali, S.N., 2010, "Influence of Transmural Pressure and Cytoskeletal Structure on NF-κB Activation in Respiratory Epithelial Cells." Cellular and Molecular Bioengineering 4, no. 3, 415-427 - 415-427.
  • Dailey, H.L., Ghadiali, S.N., 2010, "Influence of Power Law Rheology on Cell Injury During Microbubble Flows." Biomechanics and Modeling in Mechanobiology 3, no. 9, 263-279 - 263-279.
  • Ghadiali, S.N., Bell, E.D., Swarts, J.D., 2010, "Timing of Tensor and Levator Veli Palatini Force Applications Determines Eustachian Tube Active Resistance Patterns during the Forced Response Test." Auris Nasus Larynx 6, no. 37, 720-729 - 720-729.
  • Sheer, F.J, Swarts, J.D., Ghadiali, S.N., 2010, "Finite Element Analysis of Eustachian Tube Function in Cleft Palate Infants Based on Histological Reconstructions." Cleft Palate Craniofacial Journal 6, no. 47, 600-610 - 600-610.


  • Ghadiali, S.N., 2009, "Invited Editorial: Making "Time" for Alveolar Recruitment." Journal of Applied Physiology no. 106, 751-752 - 751-752.
  • Yalcin, H.C., Hallow, K.M., Wang, J., Ou-Yang, H.D., Ghadiali, S.N., 2009, "Influence of Cytoskeletal Structure and Mechanics on Epithelial Cell Injury during Cyclic Airway Reopening." American Journal of Physiology: Lung Cell and Molecular Physiology 5, no. 297, L881-L891 - L881-L891.
  • Dailey, H.L., Ricles, L.M., Yalcin, H.C., Ghadiali, S.N., 2009, "Image-Based Finite Element Modeling of Alveolar Epithelial Cell Injury during Airway Reopening." Journal of Applied Physiology ?, no. 106, 221-232 - 221-232.


  • Ghadiali, S.N. & Gaver, D.P., 2008, "Biomechanics of Liquid-Epithelium Interactions in Pulmonary Airways." Respiratory Physiology and Neurobiology ?, no. 163, 232-243 - 232-243.
  • Wei, M.T., Zaorski, A., Yalcin, H.C., Wang, J., Hallow, M., Ghadiali, S.N., Chiou, A., Ou-Yang, H.D., 2008, "A Comparative Study of Living Cell Micromechanical Properties by Oscillatory Optical Tweezers." Optics Express ?, no. 16, 8594-8603 - 8594-8603.


  • Dailey, H.L. & Ghadiali, S.N., 2007, "Fluid-Structure Analysis of Microparticle Transport in Deformable Pulmonary Alveoli." Journal of Aerosol Science ?, no. 38, 269-288 - 269-288.
  • Kent,Melodie,Jan Lynettee; Ghadiali,Samir; Marzillier,Jutta; Perry,Susan, 2007, "Effect of mechanical forces on surfactant protein expression in alveolar lung epithelial cells." FASEB JOURNAL 21, no. 5, A552-A552 - A552-A552.
  • Yalcin, H.C., Perry, S.F., Ghadiali, S.N., 2007, "Influence of Airway Diameter and Cell Confluence on Epithelial Cell Injury in an In-Vitro Model of Airway Reopening." Journal of Applied Physiology ?, no. 103, 1796-1807 - 1796-1807.


  • Ghadiali,S; Swarts,J,D; Banks,J; Doyle,W,J, 2002, "Influence of lung surfactant on Eustachain tube mechanics." FASEB JOURNAL 16, no. 5, A1151-A1151 - A1151-A1151.


  • Ghadiali, S.; Gaver, D., 2000, "Experimental and computational investigations of surfactant physicochemical behavior during pulmonary airway opening." Annals of Biomedical Engineering 28, no. SUPPL. 1,


  • Ghadiali,S; Gaver,D,P, 1998, "Exogenous replacement surfactants reduce airway reopening stresses by interfacial remobilization." FASEB JOURNAL 12, no. 4, A171-A171 - A171-A171.


  • Gaver, D.P.; Krueger, M.A.; Ghadiali, S.N., 1997, "The influence of surfactant physicochemical properties on pulmonary interfacial flow analogues." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 36, 41-42 - 41-42.


  • "Using Alveolar Pneumocyte Self-Derived Exosomes to Modulate Lung Inflammatory Response." 2017, Presented at Biomedical Engineering Society Meeting,
  • "Guiding Tumor Cell Invasion using Non-soluble Cues in the Tumor Microenvironment." 2017, Presented at Biomedical Engineering Society Meeting,

Papers in Proceedings


  • Zielinski, R.; Mihai, C.; Ghadiali, S. "Multi-scale modeling of cancer cell migration and adhesion during epithelial-to-mesenchymal transition." (12 2011).
  • Chen, X.; Ghadiali, S. "Computational model of microbubble flows during the reopening of airways." (12 2011).
  • Higuita-Castro, N.; Mihai, C.; Hansford, D.J.; Ghadiali, S.N. "In-vitro model of the microscale alveolar environment." (12 2011).
  • Sheer, F.J.; Ghadiali, S.N. "Computational analysis of adhesion dynamics in the eustachian tube during inflammatory otitis media." (12 2011).


  • Mihai, C.; Bao, S.; Knoell, D.; Ghadiali, S.N. "Influence Of PTEN Inhibition On The Biomechanical Mechanisms Responsible For Rapid Cell Migration And Wound Repair." (1 2010).


  • Capozzi, M.T.; Swarts, J.D.; Ghadiali, S. "Influence of molecular adhesion on flow phenomena in a collapsed respiratory airway: A multi-scale analysis." (12 2005).
  • Bluestone, C.D.; Alper, C.M.; Buchman, C.A.; Felding, J.U. et al. "Eustachian tube, middle ear, and mastoid anatomy; physiology, pathophysiology, and pathogenesis." (1 2005).
  • Dailey, H.L.; Ghadiali, S.N. "Fluid-structure analysis of convective and diffusive particle transport in pulmonary alveoli." (12 2005).


  • Ghadiali, S.N.; Federspiel, W.J.; Douglas Swarts, J.; Doyle, W.J. "Measurement of Eustachian tube mechanical properties using a modified forced response test." (12 2001).
  • Gaver, D.P.; Ghadiali, S.N.; Williams, H.A.R.; Halpern, D. "Pulmonary surfactant transport in steady and unsteady flows." (12 2001).


  • Ghadiali, S.N.; Gaver, D.P. "Influence of bulk surfactant transport on airway reopening." (12 1999).


  • Hostnik, E.T.; Ham, K.; Ghadiali, S.; Habing, G. et al. "Quantification of Airflow Resistance by Computed Tomography in English Bulldogs Before and After Airway Surgery." in 2017 ACVS Surgery Summit.